Vern L Schramm Selected Research

Oral Administration

1/2021	A resistant mutant of Plasmodium falciparum purine nucleoside phosphorylase uses wild-type neighbors to maintain parasite survival.
1/2011	Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model.

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Vern L Schramm Research Topics

Disease

19	Neoplasms (Cancer) 11/2023 - 08/2003
17	Malaria 01/2021 - 12/2003
9	Infections 01/2021 - 12/2003
4	Starvation 01/2018 - 10/2004
4	Leukemia 01/2015 - 08/2008
3	Gout 01/2015 - 03/2010
2	Colorectal Neoplasms (Colorectal Cancer) 11/2023 - 01/2021
2	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 01/2020
2	Visceral Leishmaniasis (Kala Azar) 12/2015 - 01/2015
2	T-Cell Leukemia (Leukemia, T Cell) 08/2008 - 07/2002
1	Purine Nucleoside Phosphorylase Deficiency 11/2023
1	Necrosis 01/2023
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2023
1	Chagas Disease (American Trypanosomiasis) 10/2022
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2021
1	Communicable Diseases (Infectious Diseases) 01/2018
1	Ulcer 01/2018
1	Tuberculosis (Tuberculoses) 01/2017
1	Multiple Myeloma 01/2016
1	Leishmaniasis 01/2015
1	Acquired Immunodeficiency Syndrome (AIDS) 04/2012
1	Lung Neoplasms (Lung Cancer) 02/2011
1	Neoplasm Metastasis (Metastasis) 02/2011
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 08/2008
1	Meningococcal Meningitis 11/2007
1	Head and Neck Neoplasms (Head and Neck Cancer) 07/2007
1	Squamous Cell Carcinoma of Head and Neck 07/2007
1	Autoimmune Diseases (Autoimmune Disease) 01/2007
1	Mesothelioma 10/2006
1	Psoriasis (Pustulosis Palmaris et Plantaris) 03/2006
1	Genomic Instability 04/2004
1	Cholera 02/2004
1	Whooping Cough (Pertussis) 02/2004
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/2003

Drug/Important Bio-Agent (IBA)

15	purineIBA 10/2022 - 10/2004
14	EnzymesIBA 10/2022 - 08/2003
7	5'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA 11/2023 - 10/2006
7	Purine-Nucleoside PhosphorylaseIBA 01/2018 - 12/2008
5	NucleosidesIBA 01/2018 - 03/2006
4	Pemetrexed (MTA)FDA Link 01/2021 - 10/2006
4	HypoxanthineIBA 01/2018 - 10/2004
3	4'- deaza- 1'- aza- 2'- deoxy- 1'- (9- methylene)immucillin GIBA 01/2021 - 01/2018
3	Anti-Bacterial Agents (Antibiotics)IBA 11/2015 - 10/2004
2	Epinephrine (Adrenaline)FDA LinkGeneric 01/2023 - 01/2020
2	MethyltransferasesIBA 01/2022 - 01/2016
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2013
2	S-Adenosylmethionine (Ademetionine)IBA 01/2021 - 02/2011
2	Vitamin K 2 (Vitamin K2)IBA 01/2018 - 01/2017
2	NucleotidesIBA 01/2018 - 06/2012
2	Nucleic AcidsIBA 01/2018 - 01/2011
2	5'-methylthioadenosineIBA 01/2017 - 05/2007
2	Immunotoxins (Immunotoxin)IBA 01/2016 - 10/2009
2	Proteins (Proteins, Gene)FDA Link 01/2016 - 05/2004
2	pyrimidineIBA 11/2013 - 01/2011
2	PurinesIBA 09/2013 - 10/2006
2	PolyaminesIBA 02/2011 - 07/2007
2	Adenine FDA LinkGeneric 02/2011 - 10/2006
2	4'- deaza- 1'- aza- 2'- deoxy- 1'- (9- methylene)- immucillin AIBA 01/2008 - 07/2007
2	Diphtheria ToxinIBA 05/2004 - 02/2004
2	ExotoxinsIBA 05/2004 - 02/2004
1	Calcibiotic Root Canal SealerIBA 11/2023
1	Phosphates (Orthophosphate)IBA 11/2023
1	methylthio-DADMe-immucillin-AIBA 01/2023
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2023
1	Interleukin-10 (Interleukin 10)IBA 01/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023
1	Antiparasitic Agents (Antiparasitics)IBA 10/2022
1	Methionine AdenosyltransferaseIBA 01/2021
1	IsoenzymesIBA 01/2021
1	Nucleic Acid PrecursorsIBA 01/2018
1	N-Glycosyl HydrolasesIBA 01/2017
1	Histones (Histone)IBA 01/2016
1	Lysine (L-Lysine)FDA Link 01/2016
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2016
1	Meglumine AntimoniateIBA 12/2015
1	RNA (Ribonucleic Acid)IBA 11/2013
1	Antimalarials (Antimalarial Agents)IBA 06/2012
1	ProdrugsIBA 06/2012
1	Human immunodeficiency virus 1 p16 proteaseIBA 04/2012
1	Methionine (L-Methionine)FDA Link 02/2011
1	InsecticidesIBA 01/2011
1	OligonucleotidesIBA 04/2009
1	PyrimidinesIBA 04/2009
1	forodesineIBA 08/2008
1	Thioguanine (Tioguanine)FDA Link 08/2008
1	adenosylhomocysteine nucleosidaseIBA 11/2007
1	Therapeutic UsesIBA 06/2007
1	Adenosine (Adenocard)FDA LinkGeneric 05/2007
1	1- (9- deazaadenin- 9- yl)methyl- 3- hydroxy- 4- methylthiomethylpyrrolidineIBA 10/2006
1	Thomsen-Friedenreich antibodiesIBA 03/2006
1	Cholera ToxinIBA 05/2004
1	Pertussis ToxinIBA 05/2004
1	Adenosine Diphosphate (ADP)IBA 02/2004
1	NAD (NADH)IBA 02/2004
1	shikimateIBA 12/2003

Therapy/Procedure

6	Therapeutics 01/2023 - 10/2009
3	Drug Therapy (Chemotherapy) 12/2015 - 12/2003
2	Oral Administration 01/2021 - 01/2011
1	Colectomy 01/2021
1	Caloric Restriction 04/2004